Characteristics of the existing methods for the production of carotenoids from vegetable raw materials and secondary resources of its processing

Carotenoids, in particular, beta-carotene and lycopene, have high antioxidant properties and are used to prevent and treat various diseases associated with human aging. The search for new or intensification of the existing methods of their preparation from plant raw materials and the secondary resources of its processing is relevant due to the high demand for carotenoids in the food, cosmetic and pharmacological industries. The purpose of the research is to analyze the patent information for determining the most optimal and promising directions in the technology of obtaining carotenoids from vegetable raw materials. The main method of obtaining carotenoids from vegetable raw materials and secondary resources of its processing is their extraction using organic solvents. Domestic and foreign scientists have been conducting scientific research in the field of intensification of the process of extraction of carotenoids from vegetable raw materials and secondary resources of its processing in order to increase the environmental safety of the technological process and the quality of the product obtained. Various technical solutions have been proposed on pre-processing of the feedstock using ultrasound (US) effects and microwave radiation, as well as enzymes and enzyme preparations for carotenoids. Analysis of foreign and domestic patent information has shown that studies in the field of integrated use of physical (ultrasound and microwave radiation) and biotechnological (enzymes and enzyme preparations) of pretreatment of the initial raw materials are most promising to increase the efficiency of the extraction of carotenoids from vegetable raw materials and secondary resources of its recycling.

1. New method of extracting a high purity licopin from tomatoes: patent CN101823934 C07C 11/21, C07C 7/00, C07C 7/10 / Han Jianmin, Pu Lumei, Wang Chong, Xue Huali, Xue Lixin, Yang Min; Applicant and patent holder: Pu Lumei; № 201010150512.8; stage. 04/16/2010; publ. 09/08/2010 (in Russ).

2. Ways of obtaining licopin: patent WO / 2003/028481, C09B 61/00 / Chen Huanzhong; Applicant and Patent holder: Xinjiang Jinqi Industry Limited; No. PCT / CN2002 / 000080; stage. 09/28/2001; publ. 10/04/2003 (in Russ).

3. Method for producing crystallized liquor from tomato paste: patent CN108244556 A23L 19/00, A23L 27/60, A23L 29/00, C07C 7/00, C07C 7/10, C07C 11/21 / Chen Hongmao, Li Lian; Applicant and Patent holder: Tianjin Waysun Tomato Products Co., Ltd; № 201810025711.2; stage. 11/01/2018; publ.06/07/2018 (in Russ).

4. Method for producing crystalline lycopin and / or oleoresina of a licopin of tomato paste: patent CN1298904 C09B 61/00 / Wen Gang, Hu Guang, Li Xin; Applicant and Patente Tel: Shengginghong Science and Technology Investment Development Co Ltd, Xinjiang; № 00128226.3; stage. 18/12/2000; publ. 13/06/2001 (in Russ).

5. The method of deep processing of tomatoes: patent CN101248861 A23L 1/212 / Liu Hongtao; Applicant and patent holder: Liu Hongtao; № 200710084843.4; stage. 02/22/2007; publ. 27/08/2008 (in Russ).

6. Method for producing beta carotene from carrots: patent CN101096355 C07C 403/24 / Dai Bin, Hu Xiaoming; Applicant and patent holder: DAI BIN; № 200610094872.4; stage. 28/06/2006; publ. 02/01/2008 (in Russ).

7. Method for obtaining individual carotenoids: patent RU2648452, A61K 36/00, A61K 35/56, A61K 35/612, B01D 11/02 / Kareboyan A.G., Painova S.V., Stepanova E.F.; Applicant and patent holder: Federal State Budgetary Educational Institution of Higher Education «Volgograd State Medical University» of the Ministry of Health of the Russian Federation; № 2016148100; stage. 12/07/2016; publ. 26/03/2018. Bul. № 9 (in Russ).

8. Method for producing licopin: patent US 5858700, C12N 1/00, C12P 23/00, A61K 36/00, A61K 36/06, A61K 36/062, A61K 36/18 / Ausich Rodney L., Sanders David J.; Applicant and patent holder: KEMIN FOODS, LC; № 08832282; stage. 03/04/1997; publ. 01/12/1999 (in Russ).

9. Method for producing individual caroteninoids: patent RU2172608, A23L 1/212, A61K 35/78 / Gazev Azhub Ibrahimovich; Applicant and patent holder: Gaziev Azhub Ibragimovich; № 2000125003; stage. 04/10/2000; publ. 27/08/2001. Bul. № 24 (in Russ).

10. Method for producing a Tomato Preparation with High Licopin Tomato: patent KR1020090017239 A23L 1/212, C07F 3/06, A23L 2/02 / Kim, IL SUK; Applicant and Patente Tel: Jinju National University Industry-Academia Cooperation Foundation; № 1020070081834; stage. 14/08/2007; publ. 18/02/2009 (in Russ).

11. Licopin extraction method using microwave: patent CN102070392 C07C 11/2, C07C 7/00 / Wu Jing; Applicant and patent holder: Huzhou Llissy Biology Technology Co., Ltd.; № 200910154643.0; stage. 23/11/2009; publ. 05/25/2011 (in Russ).

12. Method for producing vegetable oil with high content of Licopin: patent CN101148631 C11B 1/10 / Zhang Kunsheng, Jiang Hong, Ren Yunxia; Applicant and patent holder: Tianjin Commercial University; № 200710150128.6; stage. 11/09/2007; publ. 26/03/2008 (in Russ).

13. Method of extraction licopin from tomatoes: patent CN 1364832 C09B 61/00 / Wang Weiqiang, Guan Congsheng, Li Aiju; applicant and patent holder: Shangdong Univ; № 02110069.1; stage. 07/02/2002; publ. 21/08/2002 (in Russ).

14. Method of extraction of a highly concentrated high-yield album from a watermelon using supercritical CO2-extraction: patent KR1020080069284 A61K 36/42, A61P 39/06, B01D 11/02 / Kim, Chul Jin; Kim, in ho; CHO, YOUNG JIN; Kim, Chong Tai; Kim, in hwan; Oh, Hyun Jung; Kim, Sung Soo; Applicant and patent holder: Korea Food Research Institute; № 1020070006787; stage. 23/01/2007; publ. 28/07/2008 (in Russ).

15. Method of extraction of nutrient components from carrots by supercritical CO2-extraction: patent CN101779788 A23L 1/28, A23L 15. / Guo Wenkai; applicant and patent holder: Guo Wenkai; № 201010145082.0; stage. 09/04/2010; publ. 21/07/2010 (in Russ).

16. Method of extraction of beta carotene from sea buckthorn: patent CN101747247 C07C 403/24 / Li Gang; Applicant and patent holder: Qingdao General Health Bio-Science Co., LLC; № 200910263590; stage. 22/12/2009; publ. 06/23/2010 (in Russ).

17. Method for producing Licopin: patent CN107056574 C07C 7/00 / Wang Qiaosong, Lu Xin, XU Li; Applicant and patent holder: Shenzhen Jiangmu Industry Co., Ltd; № 102017000062650; stage. 02/03/2017; publ. 18/08/2017 (in Russ).

18. Method for producing Licopin Pat.CN101289364 C09B 61/00 / [Text] / Chen Xinjuan, Yang Yuejian, Wang Rongqing, Ye Qingjing, Zhou Guozhi, Li Zhimiao, Yao Zhuping; Applicant and patent holder: Zhejiang Academy of Agricultural Science, – № 200810061661.x; Stage. 21/05/2008; publ. 10/22/2008 (in Russ).

19. Method of extraction of beta carotene from persimmon patent CN105924376 C07C 403/24 / Mo Kentang; Applicant and Patent holder: Liuzhou Sannong Science & Technology Co., Ltd; № 201610283101.3; stage. 05/03/2016; publ. 07/09/2016 (in Russ).

20. Method of beta carotene extraction from common mango: patent CN105924377 C07C 403/24 / Mo Kentang; Applicant and Patentelandel: Liuzhou Sannong Science & Technology Co., Ltd; № 201610283102.8; stage. 05/03/2016; publ. 07/09/2016 (in Russ).

21. Ecological method of obtaining high-purity beta carotene: patent CN112778182 C07C 403/24 / Mao Jihua, TU Zongcai, Zhang Lu, Jia Xiaoyan, Fu Qiaoqin; applicant and patent holder: Jiangxi Normal University; № 202110306602.x; stage. 23/03/2021; publ. 11/05/2021 (in Russ).

22. Method of licopin extraction from tomatoes: patent CN104370680 C07C 11/21, C07C 7/00, C07C 7/10, C09B 61/00 / Li Yong, Liu Wenbin; Applicant and patent holder: Xi’an Miyi Biotechnology Co., Ltd.; № 201410570234.x; stage. 23/10/2014; publ. 25/02/2015 (in Russ).

23. Method for producing a licopin of tomatoes using Lactobacillus: patent KR1020100057310 A23L 1/212, A23L 1/29, A23C 9/123 / Kim, Young Shik, Koh, Jong HO; Applicant and patent holder: Sangmyung University, Council for Industry Academic Cooperation; № 1020080116295; stage. 11/21/2008; publ. 31/05/2010 (in Russ).

24. Method for producing Licopin: patent CN1493622 C09B 61/00 / Liu Liguo, Liu Yuanhong; Applicant and patent holder: Guangzhou Youbao Industry Co., Ltd.; № 3146821.7; stage. 15/09/2003; publ. 05/05/2004 (in Russ).

25. Method for producing Licopean using enzymatic processing: patent C101085989 C12P 5/02, C12N 1/20, C12R 1/59 / Ma Rongcai, Gao Junlian, Wang Min, Yang Hui, Han Meilin, Sun Xiaohong; Applicant and Patentemy Tel: Beijing Academy of Agriculture and Forestry Sciences; № 00710122895.6; stage. 15/09/2003; publ. 12/12/2007 (in Russ).

26. Method for producing a natural food dye from vegetable raw materials and waste of vegetable raw materials and natural food dye, obtained in this method: patent RU2285708, C09B 61/00 / Ryzhova N.V., Ivanova L.A., Butova S.N.; Applicant and patent holder: State Educational Institution of Higher Professional Education «Moscow State University of Food Products»; № 2005138928/1; stage. 15/12/2005; publ. 20.10.2006. Bul. № 29 (in Russ).